Ethyl Acetoacetate → HCID 178429414、化合物
反応式
C(=O)(O)O.[NH2:5][C:6]([NH2:8])=[NH:7].[C:9](OCC)(=[O:14])[CH2:10][C:11]([CH3:13])=O>C(O)C>[CH3:13][C:11]1[NH:5][C:6]([NH2:8])=[N:7][C:9](=[O:14])[CH:10]=1参加物
4
実験手順
Dry ethanol (600 mL), 91.89 g of guanidine carbonate, and 146.1 g of ethyl acetoacetate were added to a 1 L flask. The reaction solution was gradually heated to reflux temperature and stirred overnight. Ethanol (300 mL) was evaporated, and the reaction mixture was heated under reflux for two hours. After the reaction mixture was cooled, 300 mL of hexane was added. The resulting precipitate was filtered, washed and dried. 119.3 g of 6-methyl-iso cytosine was obtained.
後処理
- temperatureThe reaction solution was gradually heated
- temperatureto reflux temperature
- customEthanol (300 mL) was evaporated
- temperaturethe reaction mixture was heated
- temperatureunder reflux for two hours
- temperatureAfter the reaction mixture was cooled
- addition300 mL of hexane was added
- filtrationThe resulting precipitate was filtered
- washwashed
- customdried
出典と根拠
- ORDレコード
- ord-d0a2792311094e53ba927cdb4a416d7a
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06858359B2
反応ノート
読み込み中…