2-Phenylaminomethylene-malonic acid diethyl ester → HCID 178469510、化合物
反応式
C(O[C:4](=[O:19])[C:5](=[CH:11][NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])C>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[OH:19][C:4]1[C:14]2[C:13](=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:12]=[CH:11][C:5]=1[C:6]([O:8][CH2:9][CH3:10])=[O:7]参加物
3
反応条件
- 温度
- 80 °C
実験手順
The 2-phenylaminomethylene-malonic acid diethyl ester was refluxed in Dowtherm® for 15 min to 2 h. The reaction mixture was cooled to 80° C. and solid was collected by filtration and washed with hexane to yield crude ethyl 4-hydroxy-quinoline-3-carboxylate 2a which was used in next step without further purification.
後処理
- filtrationsolid was collected by filtration
- washwashed with hexane
出典と根拠
- ORDレコード
- ord-aca77ffdeac44d3e983f530c8670cda2
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863266B2
反応ノート
読み込み中…