反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10]([O:12][CH3:13])[N:9]=[C:8]([CH2:14][NH:15][C:16]([NH:18]C(OCC2C3C=CC=CC=3C3C2=CC=CC=3)=O)=S)[CH:7]=1)=[O:5])[CH3:2].C1CCC(N=C=NC2CCCCC2)CC1>C1(C)C=CC=CC=1>[NH:18]=[C:16]1[N:9]2[C:10]([O:12][CH3:13])=[CH:11][C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:7][C:8]2=[CH:14][NH:15]1参加物
4
実験手順
1.17 g (2.38 mmol) of N-(4-ethoxycarbonyl-6-methoxypyridin-2-ylmethyl)-N′-(fluoren-9-ylmethyloxycarbonyl)thiourea (20e) were treated with 491 mg (2.38 mmol) of DCC in 25 ml of toluene and refluxed for six hours. After standing overnight at RT, the mixture was freed from the solvent and the residue was chromatographed on silica gel (heptane/ethyl acetate 75:25→ethyl acetate/methanol 90:10), it being possible to isolate 88 mg of the title compound.
後処理
- temperaturerefluxed for six hours
- customthe residue was chromatographed on silica gel (heptane/ethyl acetate 75:25→ethyl acetate/methanol 90:10), it
出典と根拠
- ORDレコード
- ord-26a9d4dd61c04d089dbadc506405d775
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863269B2
関連ノート
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