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HRID 249830作成日：2026年10月26日

(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride → (S)-N-(quinuclidine-8-yl)-2-(piperidin-1-yl)benzoxazole-4-carboxamide

https://huagongshe.com/reaction/249830

反応式

関与物質

役割名称HCID仕込み量
反応物(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochlorideHCID 12494973—
反応物2-(Piperidin-1-yl)benzoxazole-4-carboxylic acidHCID 66873780—
生成物(S)-N-(quinuclidine-8-yl)-2-(piperidin-1-yl)benzoxazole-4-carboxamideHCID 66873975—

反応手順

Following general procedure GP-C1, a mixture of 2-(piperidin-1-yl)benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-(piperidin-1-yl)benzoxazole-4-carboxamide which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07863271B2
出典データセットuspto-grants-2011_01
ORD IDord-c453c317dff3429d83613009dea980ee
出典メモuspto-grants-2011_01