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HRID 249831作成日：2026年10月27日

(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride → (S)-N-(quinuclidine-8-yl)-2-(phenylamino) benzoxazole-4-carboxamide

https://huagongshe.com/reaction/249831

反応式

関与物質

役割名称HCID仕込み量
反応物(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochlorideHCID 12494973—
反応物2-(Phenylamino)benzoxazole-4-carboxylic acidHCID 66873988—
生成物(S)-N-(quinuclidine-8-yl)-2-(phenylamino) benzoxazole-4-carboxamideHCID 86623718—

反応手順

Following general procedure GP-C1, A mixture of 2-(phenylamino)benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-(phenylamino) benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07863271B2
出典データセットuspto-grants-2011_01
ORD IDord-4806df97d27f4a738f260cf462630a73
出典メモuspto-grants-2011_01