反応式
[CH3:1][S:2][C:3]1[O:4][C:5]2[C:6](=[C:8]([C:12]([OH:14])=O)[CH:9]=[CH:10][CH:11]=2)[N:7]=1.Cl.Cl.[NH2:17][C@H:18]1[CH:23]2[CH2:24][CH2:25][N:20]([CH2:21][CH2:22]2)[CH2:19]1>>[N:20]12[CH2:19][C@@H:18]([NH:17][C:12]([C:8]3[CH:9]=[CH:10][CH:11]=[C:5]4[O:4][C:3]([S:2][CH3:1])=[N:7][C:6]=34)=[O:14])[CH:23]([CH2:24][CH2:25]1)[CH2:22][CH2:21]2参加物
3
実験手順
Following general procedure GP-C1, a mixture of 2-(methylthio)benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-(methylthio)benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.
出典と根拠
- ORDレコード
- ord-1253244db09141cabc9b049a73721c3e
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863271B2
関連ノート
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