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(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride → (S)-N-(quinuclidine-8-yl)-2-((2S,6R)-2,6-dimethylmorpholino)benzoxazole-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride | HCID 12494973 | — |
| 反応物 | 2-[(2S,6R)-2,6-dimethylmorpholino]benzoxazole-4-carboxylic acid | HCID 66874839 | — |
| 生成物 | (S)-N-(quinuclidine-8-yl)-2-((2S,6R)-2,6-dimethylmorpholino)benzoxazole-4-carboxamide | HCID 66873542 | — |
反応手順
Following general procedure GP-C1, a mixture of 2-[(2S,6R)-2,6-dimethylmorpholino]benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-((2S,6R)-2,6-dimethylmorpholino)benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07863271B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-f1b8af22538b425c9246877a3c221908 |
| 出典メモ | uspto-grants-2011_01 |