(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride → (S)-N-(quinuclidine-8-yl)-2-(3-phenylmorpholino)benzoxazole-4-carboxamide

HRID 249837

反応式

HRID 249837 の反応式
[C:1]1([CH:7]2[N:12]([C:13]3[O:14][C:15]4[C:16](=[C:18]([C:22]([OH:24])=O)[CH:19]=[CH:20][CH:21]=4)[N:17]=3)[CH2:11][CH2:10][O:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.Cl.[NH2:27][C@H:28]1[CH:33]2[CH2:34][CH2:35][N:30]([CH2:31][CH2:32]2)[CH2:29]1>>[N:30]12[CH2:29][CH:28]([NH:27][C:22]([C:18]3[CH:19]=[CH:20][CH:21]=[C:15]4[O:14][C:13]([N:12]5[CH2:11][CH2:10][O:9][CH2:8][C@@H:7]5[C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)=[N:17][C:16]=34)=[O:24])[CH:33]([CH2:34][CH2:35]1)[CH2:32][CH2:31]2

参加物

3

反応物 2

HCID 12494973(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochlorideHCID 668739912-(3-Phenylmorpholino)benzoxazole-4-carboxylic acid

生成物 1

HCID 66873796(S)-N-(quinuclidine-8-yl)-2-(3-phenylmorpholino)benzoxazole-4-carboxamide

実験手順

Following general procedure GP-C1, a mixture of 2-(3-phenylmorpholino)benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-(3-phenylmorpholino)benzoxazole-4-carboxamide which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

出典と根拠

ORDレコード
ord-f5d75d2ffe4c497b88d7a0603fee1245
出典データセット
uspto-grants-2011_01
特許番号
US07863271B2

関連ノート

読み込み中…