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Hexane → (RS)-S-[3-({[6-Methoxy-4-(1,3,4-thiadiazol-2-ylamino)quinazolin-7-yl]oxy}-methyl)phenyl]-S-methylsulphoximide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexane | HCID 8058 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | Dichloromethane methanol | HCID 21226129 | — |
| 反応物 | (RS)-N-(Ethoxycarbonyl)-S-methyl-S-[3-({[6-methoxy-4-(1,3,4-thiadiazol-2-ylamino)quinazolin-7-yl]oxy}methyl)phenyl]sulphoximide | HCID 57788000 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (RS)-S-[3-({[6-Methoxy-4-(1,3,4-thiadiazol-2-ylamino)quinazolin-7-yl]oxy}-methyl)phenyl]-S-methylsulphoximide | HCID 57788009 | 35% |
反応手順
According to GWP 6, the reaction of (RS)-N-(ethoxycarbonyl)-S-methyl-S-[3-({[6-methoxy-4-(1,3,4-thiadiazol-2-ylamino)quinazolin-7-yl]oxy}methyl)phenyl]-sulphoximide (37 mg, 0.072 mmol) with sodium ethoxide (25 mg, 0.39 mmol) and chromatographic purification (silica gel, hexane, dichloromethane/methanol: 0→15% methanol) gives the desired product in 35% yield (11 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07863283B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-ab768e0c7e1741d5851b6ea756d7c4cf |
| 出典メモ | uspto-grants-2011_01 |