Piperidine → 6-Bromo-7-methoxy-3,4-dihydroquinazolin-4-one
反応式
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([Br:13])=[CH:7][C:3]=1[C:4](O)=[O:5].[NH:14]1CCCC[CH2:15]1.N1C=NC=NC=1>CO>[Br:13][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][C:9]=1[O:11][CH3:12])[N:1]=[CH:15][NH:14][C:4]2=[O:5]参加物
5
実験手順
2-Amino-5-bromo-4-methoxybenzoic acid (1.56 g, 6.34 mmol) is dissolved in methanol (15 ml), treated with piperidine (0.063 ml, 0.63 mmol) and 1,3,5-triazine (772 mg, 9.5 mmol) and refluxed for one hour. After cooling to room temperature, the resulting crystals are filtered off with suction and washed with methanol. The desired product is obtained in 63% yield (1.01 g).
後処理
- temperaturerefluxed for one hour
- filtrationthe resulting crystals are filtered off with suction
- washwashed with methanol
出典と根拠
- ORDレコード
- ord-1a5c152eb7c94aef8e7db017f347b61c
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863283B2
反応ノート
読み込み中…