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1,1'-Thiocarbonyldi-2(1H)-pyridone → 4-Isothiocyanato-6-phenoxypyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-Thiocarbonyldi-2(1H)-pyridone | HCID 853162 | — |
| 反応物 | 6-Phenoxypyrimidin-4-amine | HCID 57476566 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Isothiocyanato-6-phenoxypyrimidine | HCID 57476567 | 192.5% |
反応手順
A mixture of 6-phenoxypyrimidin-4-amine (0.288 g, 1.538 mmol) and 1,1′-thiocarbonyldipyridin-2(1H)-one (0.357 g, 1.538 mmol) in DCM was stirred at rt for 18 h. The pale orange mixture was purified by silica gel chromatography (5-35% ethyl acetate-hexanes) to afford 4-isothiocyanato-6-phenoxypyrimidine (0.55 g, 2.96 mmol, 85% yield) a yellow oil. LCMS R.T.=2.78; [M+H]+=229.94.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07863291B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-ef4999bd6e90407d8cd1bd62a9c84419 |
| 出典メモ | uspto-grants-2011_01 |