Triethylamine → 1-(3-chloro-1-phenyl-propyl)-1H-indole

HRID 250193ノート

反応式

HRID 250193 の反応式
[N:1]1([CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:11][CH2:12]O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C(N(CC)CC)C.CS([Cl:31])(=O)=O.C([O-])(O)=O.[Na+].[Li+].[Cl-]>C(Cl)Cl>[Cl:31][CH2:12][CH2:11][CH:10]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

7

反応物 5

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 433294Lithium ChlorideHCID 516892Sodium BicarbonateHCID 235559373-Indol-1-yl-3-phenyl-propan-1-ol

生成物 1

HCID 580884211-(3-chloro-1-phenyl-propyl)-1H-indole収率 81.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-indol-1-yl-3-phenyl-propan-1-ol (0.166 g, 0.66 mmol) in CH2Cl2 (20 mL) and triethylamine (0.087 g, 0.85 mmol) at 0° C. was added methanesulfonyl chloride (0.083 g, 0.72 mmol), and the mixture was stirred for 1 hour at room temperature. The reaction mixture was poured into an aqueous saturated solution of NaHCO3 (50 mL) and extracted with CH2Cl2 (2×50 mL). The organic layer was dried over Na2SO4, and the solvent was removed under vacuum. The residue was diluted in MeCN (50 mL) and treated with LiCl (0.084 g, 1.98 mmol), and the reaction mixture was heated to reflux temperature for 24 hours. The solvent was removed under vacuum and the crude product was chromatographed (SiO2, Hexanes/EtOAc, 9:1) to afford 0.145 g (81% yield) of 1-(3-chloro-1-phenyl-propyl)-1H-indole as an oil.

後処理

  1. extractionextracted with CH2Cl2 (2×50 mL)
  2. dry with materialThe organic layer was dried over Na2SO4
  3. customthe solvent was removed under vacuum
  4. additionThe residue was diluted in MeCN (50 mL)
  5. temperaturethe reaction mixture was heated
  6. temperatureto reflux temperature for 24 hours
  7. customThe solvent was removed under vacuum
  8. customthe crude product was chromatographed (SiO2, Hexanes/EtOAc, 9:1)

出典と根拠

ORDレコード
ord-dbf3b3b5c36146ff8f476f6e7eaca870
出典データセット
uspto-grants-2011_01
特許番号
US07863305B2

反応ノート

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