Methane → Methyl 2-aminothiazole-5-carboxylate

HRID 250214

反応式

HRID 250214 の反応式
[CH3:1][O:2][C:3](=[O:8])[CH:4](Cl)[CH:5]=O.[NH2:9][C:10]([NH2:12])=[S:11].C>O>[CH3:1][O:2][C:3]([C:4]1[S:11][C:10]([NH2:12])=[N:9][CH:5]=1)=[O:8]

参加物

5

反応物 3

HCID 297MethaneHCID 2723790ThioureaHCID 14355182Methyl 2-chloro-3-oxopropanoate

生成物 1

HCID 238005Methyl 2-aminothiazole-5-carboxylate収率 44.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2.4 g of 2-chloro-3-oxo-propionic acid methyl ester (8-2), water 20 ml and 1.75 g of thiourea was refluxed for 2 hours. The mixture was cooled to room temperature and 0.25 g of norit was added and filtered. A solution of 2.5N sodium hydroxide was added to the filtrate until neutral pH. The filtration yielded 1.23 g (44%) of 2-amino-thiazole-5-carboxylic acid methyl ester (8-3).

後処理

  1. temperaturewas refluxed for 2 hours
  2. filtrationfiltered
  3. additionA solution of 2.5N sodium hydroxide was added to the filtrate until neutral pH
  4. filtrationThe filtration

出典と根拠

ORDレコード
ord-af243986fd30419bacfe52c2db0020cf
出典データセット
uspto-grants-2011_01
特許番号
US07863306B2

関連ノート

読み込み中…