1-Chloro-4-hydroxyisoquinoline-3-carboxylic acid → (S)-2-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-3-hydroxy-propionic acid

反応式

[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([OH:15])=O)[N:3]=1.Cl.C([O:21][C:22](=[O:31])[C@@H:23]([NH2:30])[CH2:24][O:25]C(C)(C)C)(C)(C)C>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([NH:30][C@@H:23]([CH2:24][OH:25])[C:22]([OH:31])=[O:21])=[O:15])[N:3]=1

参加物

反応物 2

HCID 110205201-Chloro-4-hydroxyisoquinoline-3-carboxylic acid

HCID 16211506H-Ser(tBu)-OtBu HCl

生成物 1

HCID 86595449(S)-2-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-3-hydroxy-propionic acid

実験手順

Prepared in analogy to Example A-2 e) and f) from 1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid from Example A-2 d) and (S)-2-amino-3-tert-butoxy-propionic acid tert-butyl ester hydrochloride; MS-(+)-ion: M+1=310.9 amu.

出典と根拠

ORDレコード: ord-882e7a22a1244df28bf46686d44a5926
出典データセット: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07863292B2

反応ノート

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