methyl D-alaninate → (R)-2-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-propionic acid methyl ester

HRID 250317

反応式

HRID 250317 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([OH:15])=O)[N:3]=1.[CH3:16][O:17][C:18](=[O:22])[C@@H:19]([CH3:21])[NH2:20]>>[CH3:16][O:17][C:18](=[O:22])[C@H:19]([NH:20][C:13]([C:4]1[N:3]=[C:2]([Cl:1])[C:11]2[C:6]([C:5]=1[OH:12])=[CH:7][CH:8]=[CH:9][CH:10]=2)=[O:15])[CH3:21]

参加物

3

反応物 2

HCID 89020methyl D-alaninateHCID 110205201-Chloro-4-hydroxyisoquinoline-3-carboxylic acid

生成物 1

HCID 86595457(R)-2-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-propionic acid methyl ester

実験手順

1-Chloro-4-hydroxy-isoquinoline-3-carboxylic acid, 0.55 g, was coupled with 0.40 g of D-Alanine methyl ester analogously to Example A-54 a) and 0.200 g of off-white, solid product were obtained: MS-(+)-icon, M+1=308.8 amu.

後処理

  1. customa) and 0.200 g of off-white, solid product were obtained

出典と根拠

ORDレコード
ord-1d5fbf3a85b94c949f62768bb560fd42
出典データセット
uspto-grants-2011_01
特許番号
US07863292B2

関連ノート

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