Hydrochloric Acid → HCID 11186874、化合物

HRID 250444ノート

反応式

HRID 250444 の反応式
C[O:2][C:3](=[O:25])[CH2:4][NH:5][C:6]([C:8]1[N:9]=[C:10]([Cl:24])[C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7].Cl.C([O-])(O)=O.[Na+]>>[Cl:24][C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:8]([C:6]([NH:5][CH2:4][C:3]([OH:25])=[O:2])=[O:7])[N:9]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 86014604HCID 86014604、化合物

生成物 1

HCID 11186874HCID 11186874、化合物収率 73.4%

実験手順

A mixture of [(1-chloro-4-phenyl-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester (50 mg, 0.14 mmol, Example D-74 b), and aqueous 6N HCl was stirred at ambient temperature for 11 days before the solution was neutralized by the addition of concentrated aqueous NaHCO3. The mixture was extracted with EtOAc (50 ml). The organic phase was dried over MgSO4 and concentrated in vacuo to give the title compound as a white solid (35 mg); MS-(+)-ion: M+1=341.0.

後処理

  1. extractionThe mixture was extracted with EtOAc (50 ml)
  2. dry with materialThe organic phase was dried over MgSO4
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-45750fd4af1d4b76bd7da1c1e56af97c
出典データセット
uspto-grants-2011_01
特許番号
US07863292B2

反応ノート

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