化工社化工社 化学情報印刷レポート · 研究参考用
1H-Pyrrolo(2,3-b)pyridine → Propane-1-sulfonic acid [3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1H-Pyrrolo(2,3-b)pyridine | HCID 9222 | — |
| 反応物 | 5-bromo-1H-indazole | HCID 761929 | — |
| 反応物 | 5-Fluoro-1H-pyrrolo[2,3-b]pyridine | HCID 20784462 | — |
| 反応物 | 5-Chloro-1H-pyrrolo[2,3-b]pyridine | HCID 24229213 | — |
| 反応物 | propane-1-sulfonic acid [2-fluoro-3-(5-fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-phenyl]-amide | HCID 58087704 | — |
| 反応物 | propane-1-sulfonic acid [2-fluoro-3-(1H-pyrrolo[2,3-b]pyridin-3-carbonyl)-phenyl]-amide | HCID 58087847 | — |
| 生成物 | Propane-1-sulfonic acid [3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-amide | HCID 58086733 | — |
反応手順
Using the protocol of Scheme 14, substituting 5-bromo-azaindole with either 5-chloro-7-azaindole (80, prepared as described in Example 9), 5-fluoro-7-azaindole (81, prepared as described in Example 9) or 7-azaindole in Step 6, propane-1-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-amide P-1013 (MS (ESI) [M−H+]−=394.1), propane-1-sulfonic acid [2-fluoro-3-(5-fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-phenyl]-amide P-1028 (MS (ESI) [M−H+]−=378.1), and propane-1-sulfonic acid [2-fluoro-3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-phenyl]-amide P-1056 (MS (ESI) [M+H+]+=362.2) were prepared, respectively;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07863288B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-0292e2944f1e4bd786619c33751fa9a7 |
| 出典メモ | uspto-grants-2011_01 |