1H-Pyrrolo(2,3-b)pyridine → N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-3,5-difluorobenzenesulfonamide

HRID 250632ノート

反応式

HRID 250632 の反応式
[NH2:1][C:2]1[C:3]([F:20])=[C:4]([C:9]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)=[O:10])[C:5]([F:8])=[CH:6][CH:7]=1.[Cl:21]C1C=C2C=CNC2=NC=1.N1C2C(=CC=CN=2)C=C1.[F:40][C:41]1[CH:42]=[C:43]([S:48](Cl)(=[O:50])=[O:49])[CH:44]=[C:45]([F:47])[CH:46]=1.S(Cl)(Cl)(=O)=O>>[Cl:21][C:17]1[CH:18]=[C:19]2[C:11]([C:9]([C:4]3[C:3]([F:20])=[C:2]([NH:1][S:48]([C:43]4[CH:42]=[C:41]([F:40])[CH:46]=[C:45]([F:47])[CH:44]=4)(=[O:49])=[O:50])[CH:7]=[CH:6][C:5]=3[F:8])=[O:10])=[CH:12][NH:13][C:14]2=[N:15][CH:16]=1

参加物

6

反応物 5

HCID 92221H-Pyrrolo(2,3-b)pyridineHCID 24648Sulfuryl chlorideHCID 27740583,5-Difluorobenzenesulfonyl chlorideHCID 242292135-Chloro-1H-pyrrolo[2,3-b]pyridineHCID 58086044(3-Amino-2,6-difluorophenyl)(1H-pyrrolo[2,3-b]pyridin-3-yl)methanone

生成物 1

HCID 58086516N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-3,5-difluorobenzenesulfonamide

実験手順

Additional compounds were prepared following the protocol of Scheme 67 Step 6, optionally substituting (3-Amino-2,6-difluoro-phenyl)-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone P-1801 with (3-Amino-2,6-difluoro-phenyl)-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone P-2021 (prepared per Scheme 67 Steps 1-5, substituting 5-chloro-1H-pyrrolo[2,3-b]pyridine 80 with 1H-pyrrolo[2,3-b]pyridine 94 in Step 3) and/or 3,5-difluorobenzenesulfonyl chloride 610 with an appropriate sulfonyl chloride. The following compounds were prepared by this procedure:

後処理

  1. customAdditional compounds were prepared
  2. customThe following compounds were prepared by this procedure

出典と根拠

ORDレコード
ord-4dbd065376c34c6fb7d4dd96c791eec5
出典データセット
uspto-grants-2011_01
特許番号
US07863288B2

反応ノート

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