Methylamine → 1-Isobutyl-2-amino-6-(methyliminomethyl)-1H-benzimidazole
反応式
[CH3:1][NH2:2].[CH2:3]([N:7]1[C:11]2[CH:12]=[C:13]([CH:16]=O)[CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[NH2:18])[CH:4]([CH3:6])[CH3:5]>CN(C)C=O>[CH2:3]([N:7]1[C:11]2[CH:12]=[C:13]([CH:16]=[N:2][CH3:1])[CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[NH2:18])[CH:4]([CH3:6])[CH3:5]参加物
4
実験手順
Add methylamine (3.0 mL, 6 mmol, 2M in tetrahydrofuran) to a solution 1-isobutyl-2-amino-6-formylbenzimidazole (475 mg, 2.19 mmol) in dimethylformamide (5 mL). Stir at room temperature for 18 hours. Concentrate under reduced pressure to provide the title compound (503 mg).
後処理
- concentrationConcentrate under reduced pressure
出典と根拠
- ORDレコード
- ord-4e13cb2630424527b0ce4bde33ce3931
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863310B2
反応ノート
読み込み中…