Methylamine → 1-Isobutyl-2-amino-6-(1-methyl-4-phenyl-1H-imidazol-5-yl)-1H-benzimidazole

反応式

[CH2:1]([N:5]1[C:9]2[CH:10]=[C:11]([CH:14]=[N:15][CH3:16])[CH:12]=[CH:13][C:8]=2[N:7]=[C:6]1[NH2:17])[CH:2]([CH3:4])[CH3:3].C1(C)C=CC(S([CH:27]([N+:34]#[C-:35])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)(=O)=O)=CC=1.CN>CO>[CH2:1]([N:5]1[C:9]2[CH:10]=[C:11]([C:14]3[N:15]([CH3:16])[CH:35]=[N:34][C:27]=3[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:12]=[CH:13][C:8]=2[N:7]=[C:6]1[NH2:17])[CH:2]([CH3:4])[CH3:3]

参加物

実験手順

Heat a mixture of 1-isobutyl-2-amino-6-(methyliminomethyl)-1H-benzimidazole (504 mg, 2.19 mmol), α-(p-toluenesulfonyl)benzylisocyanide (1.48 g, 5.47 mmol), methanol (7 mL), and methylamine (5.5 mL, 2M in tetrahydrofuran) in a sealed tube at 80° C. for 20 hours. Cool to room temperature and concentrate under reduced pressure. Subject residue to silica gel chromatography, eluting with a 1:1 mixture of acetonitrile and dichloromethane containing 5% methanol to provide the desired compound.