(4-Bromo-3-methylphenyl)methanol → 4-Bromo-3-methylbenzaldehyde

HRID 250859

反応式

HRID 250859 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][C:3]=1[CH3:10]>ClCCl.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][C:3]=1[CH3:10]

参加物

4

反応物 1

HCID 10987288(4-Bromo-3-methylphenyl)methanol

生成物 1

HCID 109215214-Bromo-3-methylbenzaldehyde収率 105.2%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

3.7 g (43 mmol, 10 eq) of manganese dioxide are added to a solution of 900 mg (4.3 mmol, 1 eq) of (4-bromo-3-methylphenyl)methanol in 8 mL of dichloromethane. The reaction mixture is stirred for 12 hours at room temperature. The solid is filtered off and the solvent is evaporated off. 900 mg of 4-bromo-3-methylbenzaldehyde are obtained in oil form and used in the following reaction without further purification.

後処理

  1. filtrationThe solid is filtered off
  2. customthe solvent is evaporated off

出典と根拠

ORDレコード
ord-e8546c71de014eecac7cc34dc7f089c6
出典データセット
uspto-grants-2011_01
特許番号
US07863332B2

関連ノート

読み込み中…