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N-(4-Aminobutyl)-N-methyl carbamic acid tert-butyl ester → {4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-amino]-butyl}-methyl-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(4-Aminobutyl)-N-methyl carbamic acid tert-butyl ester | HCID 2756377 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 3,5-Dimethylpyridine-2-carbaldehyde | HCID 18731683 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | {4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-amino]-butyl}-methyl-carbamic acid tert-butyl ester | HCID 58997083 | — |
反応手順
Using General Procedure B: Reaction of (4-Amino-butyl)-methyl-carbamic acid tert-butyl ester and 3,5-dimethyl-pyridine-2-carbaldehyde with NaBH(OAc)3 in CH2Cl2 gave {4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-amino]-butyl}-methyl-carbamic acid tert-butyl ester as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07863293B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-cc4bc05c439d4badafba0393c2085ef4 |
| 出典メモ | uspto-grants-2011_01 |