Ammonia → (2-Aminomethyl-4-methoxy-benzyl)-(3-methyl-pyridin-2-ylmethyl)-(1-pyridin-2-yl-ethyl)-amine

HRID 251246ノート

反応式

HRID 251246 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:11][N:12]([CH2:21][C:22]2[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][N:23]=2)[CH:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH3:14])=[C:7]([CH:10]=1)[C:8]#[N:9].N>CO.[Ni]>[NH2:9][CH2:8][C:7]1[CH:10]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=1[CH2:11][N:12]([CH2:21][C:22]1[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][N:23]=1)[CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)[CH3:14]

参加物

5

反応物 2

HCID 222AmmoniaHCID 672723475-Methoxy-2-{[(3-methyl-pyridin-2-ylmethyl)-(1-pyridin-2-yl-ethyl)-amino]-methyl}-benzonitrile

生成物 1

HCID 58997105(2-Aminomethyl-4-methoxy-benzyl)-(3-methyl-pyridin-2-ylmethyl)-(1-pyridin-2-yl-ethyl)-amine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A solution of the above nitrile (258 mg, 0.69 mmol) in MeOH saturated with NH3 (15 mL) was hydrogenated (40 psi) over Raney-nickel for 4 hours. The mixture was filtered with suction through a pad of celite, washing with excess MeOH. The filtrate was concentrated under reduced pressure, giving the crude amine as a purple foam.

後処理

  1. customfor 4 hours
  2. filtrationThe mixture was filtered with suction through a pad of celite
  3. washwashing with excess MeOH
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-0a7a779d796d4df895feea0781562885
出典データセット
uspto-grants-2011_01
特許番号
US07863293B2

反応ノート

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