Methanimidamide, N,N-diphenyl- → 2-(2-Chlorobenzoyl)-3-phenylaminoacrylonitrile

HRID 251355

反応式

HRID 251355 の反応式
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([CH2:6][C:7]#[N:8])=[O:5].[C:13]1([N:19](C2C=CC=CC=2)[CH:20]=N)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([C:6](=[CH:20][NH:19][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]#[N:8])=[O:5]

参加物

4

反応物 2

HCID 78296Methanimidamide, N,N-diphenyl-HCID 27342012-Chlorobenzoylacetonitrile

生成物 1

HCID 670242032-(2-Chlorobenzoyl)-3-phenylaminoacrylonitrile収率 52.2%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 2-chlorobenzoylacetonitrile (1.0 g, 5.6 mmol, 1.0 eq) and diphenylformamidine (1.10 g, 5.6 mmol, 1.0 eq) in 50 mL of toluene was heated to 85° C. overnight. The heat source was removed and desired product slowly began to precipitate from solution. The resulting solid was filtered and dried to provide the desired product (826 mg, 52%). HPLC (4 minute 10-90 gradient) tR 3.13 min; MS m/z 283.2 [M+H]+.

後処理

  1. customThe heat source was removed
  2. customto precipitate from solution
  3. filtrationThe resulting solid was filtered
  4. customdried

出典と根拠

ORDレコード
ord-a7048494c94a4aea8da24590b13be64b
出典データセット
uspto-grants-2011_01
特許番号
US07863314B2

関連ノート

読み込み中…