関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanimidamide, N,N-diphenyl- | HCID 78296 | — |
| 反応物 | 3-(3-Methoxyphenyl)-3-oxopropanenitrile | HCID 584716 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(3-Methoxybenzoyl)-3-phenylamino-acrylonitrile | HCID 67024286 | — |
反応手順
A solution of 3-methoxybenzoylacetonitrile (1.20 g, 68.5 mmol, 1.0 eq) and diphenylformamidine (1.34 g, 68.5 mmol, 1.0 eq) in 25 mL of toluene was stirred at room temperature for 2h then heated to 100° C. overnight. The solution was cooled and diluted with hexanes. The resulting solid was filtered and dried to provide the desired product. HPLC (4 minute 10-90 gradient) tR 3.05 min; MS m/z 279.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07863314B2 |
|---|
| 出典データセット | uspto-grants-2011_01 |
|---|
| ORD ID | ord-6dd22fdfc3474aa3af65bf73b381ac40 |
|---|
| 出典メモ | uspto-grants-2011_01 |
|---|
