Ammonia → [2-(Prop-2-en-1-yloxy)phenyl]methanamine

HRID 25151ノート

反応式

HRID 25151 の反応式
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11]Cl)[CH:2]=[CH2:3].[NH3:13]>>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][NH2:13])[CH:2]=[CH2:3]

参加物

3

反応物 2

HCID 222AmmoniaHCID 114580661-(Allyloxy)-2-(chloromethyl)benzene

生成物 1

HCID 14940440[2-(Prop-2-en-1-yloxy)phenyl]methanamine

実験手順

3.0 g (16.4 mmol) of the compound from Example I are boiled under reflux for 17 hours in 250 ml of a saturated methanolic ammonia solution. The reaction mixture is evaporated in vacuo, the residue is taken up in methanol and the mixture is evaporated again; this process is repeated a few times. The crude product is taken up in dichloromethane and extracted several times with water. The aqueous phase is evaporated to a very great extent, an oil being obtained which crystallizes on standing.

後処理

  1. customThe reaction mixture is evaporated in vacuo
  2. customthe mixture is evaporated again
  3. extractionextracted several times with water
  4. customThe aqueous phase is evaporated to a very great extent
  5. customan oil being obtained which
  6. customcrystallizes on standing

出典と根拠

ORDレコード
ord-a00cbcb54b8f47ee845db3020a23743c
出典データセット
uspto-grants-2005_02
特許番号
US06858622B2

反応ノート

読み込み中…