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Water → (S)-(1,2,3,4-tetrahydro-naphthalen-1-yl)carbamic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Aminotetralin, (S)- | HCID 7058074 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (S)-(1,2,3,4-tetrahydro-naphthalen-1-yl)carbamic acid ethyl ester | HCID 7768470 | — |
反応手順
Ethyl chloroformate (7.74 g, 71.3 mmol) is added dropwise to a mixture of (S)-1,2,3,4-tetrahydro-naphthalen-1-ylamine (10.0 g, 67.9 mmol) and K2CO3 (18.8 g, 136 mmol) in CH3CN (100 mL). The resulting mixture is stirred at room temperature overnight. Water (100 mL) is added and the mixture is extracted with ether (2×100 mL). The combined extract is washed with 1 N HCl (2×TO mL), water, dried (Na2SO4), and concentrated in vacuo to give (S)-(1,2,3,4-tetrahydro-naphthalen-1-yl)-carbamic acid ethyl ester as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07863454B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-abb2f4dc1dff47a1849b50a23c0ed4f5 |
| 出典メモ | uspto-grants-2011_01 |