Hydrochloric Acid → Pyrazino[1,2-a]indole-3-carboxylic acid hydrochloride

HRID 25160ノート

反応式

HRID 25160 の反応式
[CH:1]1[C:6]2=[CH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:5]2[CH:4]=[C:3]([C:14]([O:16]CC)=[O:15])[N:2]=1.[OH-].[K+].O.[ClH:22]>CCO>[ClH:22].[CH:1]1[C:6]2=[CH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:5]2[CH:4]=[C:3]([C:14]([OH:16])=[O:15])[N:2]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 12132803Ethyl pyrazino[1,2-a]indole-3-carboxylate

生成物 1

HCID 69607038Pyrazino[1,2-a]indole-3-carboxylic acid hydrochloride収率 34%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl pyrazino[1,2-a]indole-3-carboxylate (0.49 g, 2.0 mmol) in EtOH (30 mL) is added crushed potassium hydroxide (1.1 g, 20.0 mmol) followed by water (30 mL). The resulting dark colored solution is stirred at rt for 40 min and then neutralized with conc. HCl to pH ˜2. The acidic mixture is concentrated to dryness to afford pyrazino[1,2-a]indole-3-carboxylic acid hydrochloride. HRMS (FAB) calcd for C12H8N2O2+H 213.0664, found 213.0658.

後処理

  1. concentrationThe acidic mixture is concentrated to dryness

出典と根拠

ORDレコード
ord-5b84bc6f76324c7bb22e155f3162326e
出典データセット
uspto-grants-2005_02
特許番号
US06858613B2

反応ノート

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