Acetic Acid → 2,4'-Dibromopropiophenone

HRID 251766ノート

反応式

HRID 251766 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.C(O)(=O)C.[Br:16]Br>O>[Br:16][CH:9]([CH3:10])[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)=[O:11]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 24408Bromine2 回HCID 66312p-Bromopropiophenone

生成物 1

HCID 6039072,4'-Dibromopropiophenone収率 64%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
10 °C

実験手順

Dissolving 5.0 g (23 mmol) of 4′-bromopropiophenon into 50 milliliter of acetic acid, and adding 3.7 g (23 mmol) of bromine while cooling with ice, stirred at the temperature of 10° C. for 3 hours. After the color of bromine disappeared, adding water and an extraction was carried out using dichloro-methane. Washing the organic layer with water, it was dried with the use of sodium sulfate. The solvent was removed by distillation and the resultant crystals were washed with hexane thereby obtaining 4.3 g of 2,4′-dibromopropiophenon (yield: 63%).

後処理

  1. temperaturewhile cooling with ice
  2. extractionan extraction
  3. washWashing the organic layer with water, it
  4. dry with materialwas dried with the use of sodium sulfate
  5. customThe solvent was removed by distillation
  6. washthe resultant crystals were washed with hexane

出典と根拠

ORDレコード
ord-d5e9e381744b4dad9487ebbcb5f6bf1d
出典データセット
uspto-grants-2011_01
特許番号
US07867629B2

反応ノート

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