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6-Amino-3-chloropyridazine → 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| 反応物 | 3-(2-Bromoacetyl)benzonitrile | HCID 2735867 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 46835564 | 50% |
反応手順
1 mmol 3-(2-bromoacetyl)benzonitrile and 1 mmol 6-chloropyridazin-3-amine in 10 ml EtOH were heated to reflux for 12 h, then cooled to room temperature. The orange-red precipitate was collected by filtration, washed with cold EtOH, and air-dried to give the 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (125 mg, 50%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07868001B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-8b23bb73b09a4ae99af5a05f93b29787 |
| 出典メモ | uspto-grants-2011_01 |