Phosphorus oxychloride → Benzoic acid, 3-cyano-5-(2-methoxyethoxy)-, methyl ester

HRID 251816ノート

反応式

HRID 251816 の反応式
O=P(Cl)(Cl)Cl.[C:6]([C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:18]=1)[C:12]([O:14][CH3:15])=[O:13])(=O)[NH2:7]>ClCCCl>[C:6]([C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:18]=1)[C:12]([O:14][CH3:15])=[O:13])#[N:7]

参加物

4

反応物 2

HCID 24813Phosphorus oxychlorideHCID 57686816HCID 57686816、化合物

生成物 1

HCID 21942473Benzoic acid, 3-cyano-5-(2-methoxyethoxy)-, methyl ester収率 90.5%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

POCl3 (20 mmol) was added to the solution of methyl 3-carbamoyl-5-(2-methoxyethoxy)benzoate (15 mmol) in 35 ml 1,2-dichloroethane and stirred for 5 h at reflux. Then the solution was cooled to room temperature, poured to the ice-water and extracted with EtOAc. The combined organic phases were dried (MgSO4), filtered, and concentrated to yield methyl 3-cyano-5-(2-methoxyethoxy)benzoate (90.5%).

後処理

  1. temperatureat reflux
  2. extractionextracted with EtOAc
  3. dry with materialThe combined organic phases were dried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-2fbeac0205e94b04858c3644e0163e50
出典データセット
uspto-grants-2011_01
特許番号
US07868001B2

反応ノート

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