Water → 3-(2-Bromoacetyl)benzonitrile

HRID 251821

反応式

HRID 251821 の反応式
[Br:1]Br.[C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])(=[O:5])[CH3:4].O>CCOCC>[Br:1][CH2:4][C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 802223-Acetylbenzonitrile

生成物 1

HCID 27358673-(2-Bromoacetyl)benzonitrile

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Br2 (1 mmol) was dropwise added to a solution of 3-acetylbenzonitrile (1 mmol) in Et2O (15 ml) at 0° C., and then the mixture was stirred at r.t. for 4 h. Water was added, and the mixture was extracted with EtOAc. The organic layer was dried over Na2SO4, and was concentrated to give an oil, i.e., 3-(2-bromoacetyl)benzonitrile, which was directly used for the next step without purification.

後処理

  1. extractionthe mixture was extracted with EtOAc
  2. dry with materialThe organic layer was dried over Na2SO4
  3. concentrationwas concentrated

出典と根拠

ORDレコード
ord-bc195a55eb7041ccb0c4ce7b56ac6d09
出典データセット
uspto-grants-2011_01
特許番号
US07868001B2

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