Methylhydrazine → 1-Methyl-3-(trifluoromethyl)-1H-pyrazole

To a mixture of 18 g of 4-ethoxy-1,1,1-trifluoro-3-butene-2-one and 50 ml of methanol was added 5.7 ml of methylhydrazine, and the mixture was heated to reflux for 4 hours. The reaction mixture was allowed to cool to room temperature, concentrated under reduced pressure, and subjected to distillation under reduced pressure (60° C./15 mmHg) to obtain 8.71 g of 1-methyl-3-trifluoromethyl-1H-pyrazole of the formula:

1. temperaturethe mixture was heated
2. temperatureto reflux for 4 hours
3. concentrationconcentrated under reduced pressure
4. distillationsubjected to distillation under reduced pressure (60° C./15 mmHg)

ORDレコード

ord-649b69fbf3864b22ba70a0766c840c75

出典データセット

uspto-grants-2011_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07867949B2