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Pyridine → HCID 58230872、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 4-Amino-3-hydroxybenzoic acid | HCID 137566 | — |
| 反応物 | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 58230872 | HCID 58230872 | 85.4% |
反応手順
To a stirred solution of 4-Amino-3-hydroxy benzoic acid (0.490 g, 0.0032 mols) and pyridine (0.76 g, 0.0096 mols) in 50 ml dry THF is added 6-chloronicotinoyl chloride (0.56 g, 0.0032 mols) and the solution is stirred under nitrogen atmosphere at RT for 10 hrs and then refluxed for 3 hrs. The reaction mixture is rotary evaporated and the residue is slurried in water and filtered to get the amide (0.8 g) which is taken for the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07868033B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-ea3d1a1b1e4f451592198345544bf6c8 |
| 出典メモ | uspto-grants-2011_01 |