Ammonium Hydroxide → HCID 66857363、化合物
反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([S:14](Cl)(=[O:16])=[O:15])=[CH:11][C:10]=2[CH3:18])=[CH:5][CH:4]=1.[OH-].[NH4+:20]>CC(C)=O>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([S:14]([NH2:20])(=[O:16])=[O:15])=[CH:11][C:10]=2[CH3:18])=[CH:5][CH:4]=1参加物
4
実験手順
5-(6-Methoxy-pyridin-3-yl)-4-methyl-thiophene-2-sulfonyl chloride (0.19 g, 0.63 mmol) was dissolved in acetone (6 ml) and added dropwise to an aqueous ammonium hydroxide solution (25%, 1.2 ml). After 1 hour the solvent was removed under reduced pressure, the residue diluted with water and extracted with ethyl acetate (3×). The combined organic extracts were washed with water, brine, dried (MgSO4.2H2O), filtered and concentrated under reduced pressure to yield a crude that was purified over silica gel (n-heptane-ethyl acetate 1:2 to 2:1 v/v) to yield a beige solid: 0.12 g (62%), MS: m/e 283.0 (MH−).