2-Bromo-3-methylthiophene → 2-fluoro-5-(3-methylthiophen-2-yl)pyridine

HRID 252265ノート

反応式

HRID 252265 の反応式
Br[C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH3:7].[F:8][C:9]1[CH:14]=[CH:13][C:12](B(O)O)=[CH:11][N:10]=1>>[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:2]2[S:3][CH:4]=[CH:5][C:6]=2[CH3:7])=[CH:11][N:10]=1

参加物

3

反応物 2

HCID 843142-Bromo-3-methylthiopheneHCID 2783397(6-Fluoropyridin-3-yl)boronic acid

生成物 1

HCID 111482362-fluoro-5-(3-methylthiophen-2-yl)pyridine収率 75.9%

実験手順

This compound was prepared in analogy to Example 52, starting from 2-bromo-3-methylthiophene (2.6 g, 15 mmol) and 2-fluoro-5-pyridine-boronic acid (2.3 g, 16.5 mmol, 1.1 equiv.) to obtain 2.2 g of the desired compound as a light yellow oil. MS (ES): m/e 194.2 (M+H)

後処理

  1. customThis compound was prepared in analogy to Example 52

出典と根拠

ORDレコード
ord-208d82ef32d04263a4465caff55dc60f
出典データセット
uspto-grants-2011_01
特許番号
US07868030B2

反応ノート

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