関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Phenylisatin | HCID 12884 | — |
| 反応物 | 5-Benzothiazolamine, 2-methyl- | HCID 36229 | — |
| 生成物 | 3-[(2-Methyl-1,3-benzothiazol-5-YL)imino]-1-phenyl-1,3-dihydro-2H-indol-2-one | HCID 9999162 | 32.3% |
反応手順
5-amino-2-methylbenzothiazole (52.2 mg, 0.31 mmol) was mixed with 1-phenylisatin (69.7 mg, 0.31 mmol) and heated at 140° C. for 3 h. The resulting crude product was purified by preparative TLC using ethyl acetate/hexane (6:4) as the eluent to give the desired product as a yellow solid (36.9 mg, 32.3%). 1H NMR Data: δ 7.9-6.7 (m, 12H), 2.9 (s, 3H). ESI-MS m/z found 370 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07868034B2 |
|---|
| 出典データセット | uspto-grants-2011_01 |
|---|
| ORD ID | ord-7e87faeaf79642bfb5ee9f1681e043ec |
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| 出典メモ | uspto-grants-2011_01 |
|---|
