Methyl 4-methoxybutanoate → HCID 66888453、化合物

反応式

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][NH2:9])=[N:6][CH:7]=1.[CH3:10][O:11][CH2:12][CH2:13][CH2:14][C:15](OC)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:15]([CH2:14][CH2:13][CH2:12][O:11][CH3:10])=[N:9][N:8]=2)[CH:7]=1

参加物

反応物 2

HCID 542317Methyl 4-methoxybutanoate

HCID 115356995-Bromo-2-hydrazinopyridine

生成物 1

HCID 66888453HCID 66888453、化合物

実験手順

A mixture of 18.80 g of (5-bromopyridin-2-yl)hydrazine [77992-44-0] and 14.54 g of methyl 4-methoxybutyrate [29006-01-7] is heated to reflux over 16 hours. The reaction solution is subsequently cooled and purified by means of flash chromatography (SiO2 60F). The title compound is identified on the basis of the Rf value.

後処理

temperatureis heated
temperatureto reflux over 16 hours
temperatureThe reaction solution is subsequently cooled
custompurified by means of flash chromatography (SiO2 60F)

出典と根拠

ORDレコード: ord-5ff049fd4acc42c1a6ba190671a246db
出典データセット: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07868036B2

反応ノート

読み込み中…

参加物