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Potassium Carbonate → 1-(2-Amino-3-nitrophenoxy)-2,3-epoxypropane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Glycidyl tosylate | HCID 160868 | — |
| 反応物 | 2-Amino-3-Nitrophenol | HCID 4115495 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 1-(2-Amino-3-nitrophenoxy)-2,3-epoxypropane | HCID 11344838 | — |
反応手順
21.7 g (0.095 mol) of glycidyl tosylate, 10 g (0.0475 mol) of 2-amino-3-nitrophenol and 6.5 g of crushed K2CO3 are mixed in acetone and the mixture is heated at reflux for 18 hours. The mixture is filtered and the solvent is evaporated under reduced pressure. The crude reaction product is purified by flash chromatography, elution being carried out with a 9/1 hexane/ethyl acetate mixture. The title compound is obtained. M.p.: 7°-78° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858629B1 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-e07988679b094e7aa963e37ef2a90aed |
| 出典メモ | uspto-grants-2005_02 |