Chloroacetaldehyde → 6-Bromoimidazo[1,2-a]pyrimidine

HRID 252361ノート

反応式

HRID 252361 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5]([NH2:8])=[N:6][CH:7]=1.Cl[CH2:10][CH:11]=O>C(=O)([O-])O.[Na+]>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([CH:10]=[CH:11][N:8]=2)[CH:7]=1

参加物

4

反応物 2

HCID 33ChloroacetaldehydeHCID 2313102-Amino-5-bromopyrimidine

生成物 1

HCID 269676226-Bromoimidazo[1,2-a]pyrimidine

試薬・触媒・溶媒 1

HCID 516892Sodium Bicarbonate溶媒

反応条件

温度
25 °C

実験手順

50 mmol of 5-bromo-pyrimidin-2-ylamine are dissolved in 200 ml of saturated aqueous sodium hydrogencarbonate solution. 55 mmol of chloroacetaldehyde are added to the reaction mixture and the mixture is stirred for 24 hours at 25° C. The mixture is extracted with ethyl acetate (3×300 ml) and the combined extracts are dried over sodium sulphate and evaporated under reduced pressure. Flash chromatography (SiO2 60F) of the residue provides the title compound which is identified on the basis of its Rf-value.

後処理

  1. extractionThe mixture is extracted with ethyl acetate (3×300 ml)
  2. dry with materialthe combined extracts are dried over sodium sulphate
  3. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-de52d2604dca48af89272bdaf45e2e80
出典データセット
uspto-grants-2011_01
特許番号
US07868036B2

反応ノート

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