化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → (S)-3-(2-Amino-3-nitrophenoxy)-1,2-epoxypropane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester | HCID 146490 | — |
| 反応物 | 2-Amino-3-Nitrophenol | HCID 4115495 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | (S)-3-(2-Amino-3-nitrophenoxy)-1,2-epoxypropane | HCID 15049327 | 84.3% |
反応手順
5 g (0.032 mol) of 2-amino-3-nitrophenol, 8 g (0.032 mol) of (S)-(+)-glycidyl 3-nitrobenzenesulfonate and 8.9 g of K2CO3 are mixed in 80 ml of acetone and the mixture is refluxed for 18 hours. Filtration is carried out, the solvent is evaporated under reduced pressure and the crude product is purified by flash chromatography, elution being carried out with a 7/3 cyclohexane/ethyl acetate mixture. The solid product obtained is triturated in ethyl ether and 5.67 g of the title product are obtained. M.p.: 107-109°. αD+28.1 (c=0.5%, MeOH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858629B1 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-f4b14f780c4148528ec5549cc4115d8e |
| 出典メモ | uspto-grants-2005_02 |