Pseudosaccharin chloride → HCID 178456251、化合物

HRID 25248ノート

反応式

HRID 25248 の反応式
Cl[C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4](=[O:12])(=[O:11])[N:3]=1.Cl.Cl.[C:15]([C:17]1([NH:26][C:27](=[O:35])[CH:28]([NH2:34])[CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH3:25])[CH2:19][CH2:18]1)#[N:16]>>[C:15]([C:17]1([NH:26][C:27](=[O:35])[CH:28]([NH:34][C:2]2[C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[S:4](=[O:12])(=[O:11])[N:3]=2)[CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])[CH2:18][CH2:19][N:20]([CH2:23][CH2:24][CH3:25])[CH2:21][CH2:22]1)#[N:16]

参加物

3

反応物 2

HCID 64783Pseudosaccharin chlorideHCID 865852012-Amino-4,4-dimethyl-pentanoic acid(4-cyano-1-propyl-piperidin-4-yl)amide bis hydrochloride salt

生成物 1

HCID 178456251HCID 178456251、化合物

実験手順

The title compound was prepared starting from 3-chloro-benzo[d]isothiazole 1,1-dioxide and 2-amino-4,4-dimethyl-pentanoic acid (4-cyano-1-propyl-piperidin-4-yl)amide bis hydrochloride salt according to the procedure from Example 10, except that the compound was further purified by HPLC using a 20×250 mm C18 reverse phase column with the method being 20% acetonitrile in water to acetonitrile. MS, m/z 460=M+1.

後処理

  1. customwas further purified by HPLC

出典と根拠

ORDレコード
ord-cd7600ea4c524118904099226f198a94
出典データセット
uspto-grants-2005_02
特許番号
US06858623B2

反応ノート

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