Hydrochloric Acid → HCID 178516805、化合物

HRID 252660

反応式

HRID 252660 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[C:11](=[N:16][NH:17][C:18]2[CH:23]=[CH:22][C:21]([S:24]([OH:27])(=[O:26])=[O:25])=[CH:20][CH:19]=2)[C:12]([O:14]C)=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:29][C:30]1[CH:35]=[CH:34][C:33]([NH:36][NH2:37])=[CH:32][CH:31]=1.Cl>C(O)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11](=[N:16][NH:17][C:18]3[CH:19]=[CH:20][C:21]([S:24]([OH:27])(=[O:25])=[O:26])=[CH:22][CH:23]=3)[C:12](=[O:14])[N:36]([C:33]3[CH:34]=[CH:35][C:30]([F:29])=[CH:31][CH:32]=3)[N:37]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 69982(4-Fluorophenyl)hydrazineHCID 178501728HCID 178501728、化合物

生成物 1

HCID 178516805HCID 178516805、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The crude product methyl 3-(4-nitrophenyl)-3-oxo-2-(2-(4-sulfophenyl)hydrazono)-propanoate (200 mg, 0.49 mmol) (synthesized as described for 11-1) was dissolved in ethanol (10 ml), and 4-fluorophenylhydrazine (96 mg, 0.59 mmol) and hydrochloric acid (37%, 0.2 ml) were added. The product 4-((1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-(4-fluorophenyl)-4H-pyrazol-4-ylidene)-hydrazino)-benzenesulfonic acid was isolated by filtration as a brown solid (yield 82%).

出典と根拠

ORDレコード
ord-c85c232e01a3483c8e39753a102aa145
出典データセット
uspto-grants-2011_01
特許番号
US07868185B2

関連ノート

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