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Water → 5-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylaniline | HCID 396813 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 5-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole | HCID 9882781 | — |
反応手順
Acetyl Chloride (0.09g, 1.55 mmol) was added to a solution of 5-fluoro2-(4′-amino-3′-methylphenyl)benzothiazole (0.2 g, 0.78 mmol) in chloroform (5 ml) containing triethylamine (86 mg, 0.85 mmol). The resulting solution was stirred for 30 min, then poured into water (20 ml). The organic layer was removed, dried (Na2SO4) and evaporated. Recrystallisation from ethanol gave a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858633B1 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-ae5991969bc04edba7258ddf1b0edf6e |
| 出典メモ | uspto-grants-2005_02 |