Hydrochloric Acid → 3,3,3-Trifluoro-2-(trifluoromethyl)-1,2-propanediol

HRID 252691

反応式

HRID 252691 の反応式
B.[Na].O.[OH:4][C:5]([C:14]([F:17])([F:16])[F:15])([C:10]([F:13])([F:12])[F:11])[C:6](OC)=[O:7].Cl>C(OCC)C>[F:11][C:10]([F:12])([F:13])[C:5]([C:14]([F:15])([F:17])[F:16])([OH:4])[CH2:6][OH:7]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 9877912Methyl 3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropionateHCID 178418435HCID 178418435、化合物

生成物 1

HCID 118056773,3,3-Trifluoro-2-(trifluoromethyl)-1,2-propanediol収率 96%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a mixture of 25.0 g of sodium boron hydride, 500 g of water, and 500 g of diethyl ether, with stirring, 100 g of methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate was added dropwise. The mixture was stirred for 10 hours, after which hydrochloric acid was added to quench the reaction. An organic layer was separated from the reaction mixture, concentrated, and distilled, obtaining 83.9 g of 3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol (yield 96%).

後処理

  1. stirringThe mixture was stirred for 10 hours
  2. customto quench
  3. customthe reaction
  4. customAn organic layer was separated from the reaction mixture
  5. concentrationconcentrated
  6. distillationdistilled

出典と根拠

ORDレコード
ord-cbe3052df8844e5e83630c10c2df9151
出典データセット
uspto-grants-2011_01
特許番号
US07868199B2

関連ノート

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