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Sodium Bicarbonate → HCID 178497918、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Methyl 4-(aminomethyl)benzoate hydrochloride | HCID 2729253 | — |
| 反応物 | 2,6-dichloro-1H-purine | HCID 178418875 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178497918 | HCID 178497918 | 60% |
反応手順
A suspension of 2,6-dichloro-9H-purine (1 g, 5.29 mmol), 4-aminomethyl-benzoic acid methyl ester hydrochloride (1.2 equiv., 1.28 g) and NaHCO3 (2.1 equiv., 935 mg, in water was heated at 100° C. The homogeneous solution thus formed was refluxed 30 min. The resulting white precipitate was filtered, washed with cold water and dried under vacuum giving the title compound 241 (1 g, 3.14 mmol, 60%). LRMS calc: 317.7. found: 318.3 (MH)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07868204B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-cd092192b3494a3dbb0d3d6ea9f8cd5a |
| 出典メモ | uspto-grants-2011_01 |