化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 1-Methyl-1H-indole-6-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl N-methylindole-6-carboxylate | HCID 639843 | — |
| 溶媒 | Methanol tetrahydrofuran water | HCID 21892291 | — |
| 生成物 | 1-Methyl-1H-indole-6-carboxylic acid | HCID 19819261 | 248.6% |
反応手順
Methyl 1-methyl-1H-indole-6-carboxylate 166 (1.24 mmol) was stirred with sodium hydroxide (0.59 g, 14.88 mmol) in a 2:2:1 mixture of methanol/THF/water (7.5 mL) for 36 hrs at rt to form a precipitate which was collected by filtration and lyophilized overnight to give the title compound 167 (0.54 g, 99% yield). MS: 175.06 (calc), 176.1 (obs).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07868205B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-5902ff32a3db45d1bd8d0c87b9ee4246 |
| 出典メモ | uspto-grants-2011_01 |