4-Hydrazinobenzoic acid → 4-(3,5-dimethyl-1H-pyrazol-1-yl)benzoic acid
反応式
[NH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1)[NH2:2].[CH3:12][C:13](=O)[CH2:14][C:15](=O)[CH3:16]>C(O)(C)C>[CH3:12][C:13]1[CH:14]=[C:15]([CH3:16])[N:1]([C:3]2[CH:4]=[CH:5][C:6]([C:7]([OH:9])=[O:8])=[CH:10][CH:11]=2)[N:2]=1参加物
4
実験手順
4-Hydrazinylbenzoic acid (251a, 2 g, 13.2 mmol) and pentane-2,4-dione (1.35 mL, 13.2 mmol) were dissolved in isopropanol (40 mL) and refluxed for 15 hours. The solvent was removed under reduced pressure to afford 252a as a white solid (2.85 g, 99% yield). 1H NMR: (DMSO) δ 8.04 (d, J=8.6 Hz, 2H), 7.66 (d, J=8.8 Hz, 2H), 6.14 (s, 1H), 2.39 (s, 3H), 2.22 (s, 3H).
後処理
- temperaturerefluxed for 15 hours
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-57f635c42bac416b894d346964ab70e9
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07868205B2
反応ノート
読み込み中…