Hydrochloric Acid → HCID 178518552、化合物
反応式
CC[O-].[Na+].O=[C:6]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[C:14]([O:16]CC)=O.[NH2:19][C:20]([NH2:22])=[S:21].Cl>CCO>[SH:21][C:20]1[N:19]=[C:14]([OH:16])[C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:6]=2[N:22]=1参加物
6
実験手順
700 mg of NaOEt (10 mmol; 1.0 equiv) was added to 6 mL of abs. EtOH. To this solution was added, with stirring, 2 g of ethyl 2-keto-cyclooctylcarboxylate (10 mmol; 1.0 equiv) and 1 g of thiourea (13 mmol; 1.3 equiv). The mixture was refluxed for 6 hours. After cooling, the mixture was poured onto ice and acidified with hydrochloric acid. 1.33 g of 2-mercapto-5,6,7,8,9,10-hexahydrocycloocta[d]-pyrimidine-4-ol (63% yield) was obtained as a white solid.
後処理
- additionTo this solution was added
- temperatureThe mixture was refluxed for 6 hours
- temperatureAfter cooling
- additionthe mixture was poured onto ice
出典と根拠
- ORDレコード
- ord-66e849cb72c94dfd84bcaf237c28b495
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07872000B2
反応ノート
読み込み中…