関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N-Methylethylenediamine | HCID 8014 | — |
| 反応物 | 2,5-Dibromothiazole | HCID 312394 | — |
| 反応物 | 1,2-Dichloroethane ethanol | HCID 22901612 | — |
| 触媒 | Copper | HCID 23978 | — |
| 触媒 | Cuprous chloride | HCID 62652 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | N1-(5-bromothiazol-2-yl)-N1-methylethane-1,2-diamine | HCID 86632288 | 36.6% |
反応手順
15 mg (0.24 mmol) of copper and 68 mg (0.69 mmol) of copper(I) chloride were added to a solution of 1.0 g (4.1 mmol) of 2,5-dibromothiazole and 2.2 ml (24.7 mmol) of N-methylethylenediamine in isopropanol (2.3 ml). The mixture was then heated to 70° C. for 1 h. After cooling to RT, filtration through silica gel was carried out and the filtrate was evaporated under a vacuum. 348 mg (1.5 mmol, 36%) of N1-(5-bromothiazol-2-yl)-N1-methylethane-1,2-diamine were obtained by CC (DCE/EtOH/conc. aq. NH4—OH soln. 5:1:0.06) with the residue.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07871999B2 |
|---|
| 出典データセット | uspto-grants-2011_01 |
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| ORD ID | ord-854ce2e82f524dfc9e68a65540978a77 |
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| 出典メモ | uspto-grants-2011_01 |
|---|
